Trent Bridge in Gainsborough will be closed overnight to repair potholes and make improvements to the road surface.
To allow the works to be completed, Trent Bridge, A631, Gainsborough will be closed to motorists nightly from 6pm to 6am between Monday, March 21, and Friday, March 25.
The road will be accessible during the day.
From 6pm to 6am motorists will not be able to travel west on the A631 out of Gainsborough towards Bawtry and the A1, and vice versa. The other main routes for the town will not be closed as part of these works.
Traffic travelling in this direction will be diverted via the A156 and the A1133, then join the A1 at Newark.
Steve Wiles, area highways manager, said: “The road surface has unfortunately deteriorated through wear and tear so it’s important we bring it back up to standard.
“While we appreciate their will be inconvenience to motorists, it’s important we complete this work before the Easter holidays when more people will be on the roads.”
Advance warning signs will be in place, bus operators have been informed and the diversion route will be signed.